Household Water Insecurity Is Positively Associated With Household Food Insecurity in Low- and Middle-Income Countries

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Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis

Erythropoietin (EPO) is of great interest as a therapy for many of the central nervous system (CNS) diseases and its administration is protective in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Endogenous EPO is induced by hypoxic/ischemic injury, but little is known about its expression in other CNS diseases. We report here that EPO expression in the spinal cord is induced in mouse models of chronic or relapsing-remitting EAE, and is prominently localized to motoneurons. We found a parallel increase of hypoxia-inducible transcription factor (HIF)-1 alpha, but not HIF-2 alpha, at the mRNA level, suggesting a possible role of non-hypoxic factors in EPO induction. EPO mRNA in the spinal cord was co-expressed with interferon (IFN)-gamma and tumor necrosis factor (TNF), and these cytokines inhibited EPO production in vitro in both neuronal and glial cells. Given the known inhibitory effect of EPO on neuroinflammation, our study indicates that EPO should be viewed as part of the inflammatory/anti-inflammatory network in MS

Accuracy, precision and reliability in anthropometric surveys for ergonomics purposes in adult working populations: A literature review

Anthropometric surveys are the most common method of gathering human morphometric data, used to design clothing, products and workspaces. The aim of this paper was to assess how current peer reviewed literature addresses the accuracy, reliability and precision regarding manual anthropometric surveys applied to adult working populations in the field of ergonomics. A literature review was performed in two electronic databases for finding relevant papers. A total of 312 papers were reviewed, of which 79 met the inclusion criteria. The results shown that the subjects of these publications are poorly addressed, so that only 27 studies mentioned at least one of the terms and none of the studies evaluated all of the terms. Only one paper mentioned and assessed precision and reliability of the measurement procedure. Furthermore, none of the publications evaluated accuracy. Moreover, the reviewed papers presented large differences in the factors that affect precision, reliability and accuracy. This was particularly clear in the measurer technique/training, measurement tools, subject posture and clothing. Researchers in this area should take more rigorous approaches and explicit indicators with their results should be presented in any report. Relevance for industry: It is important that scientific literature related to manual anthropometric measurements uses methods for assessing measurement error, since these data are often used to design clothing and workspaces as well as to calibrate non manual methods such as 3D scanners.</p